Contactez-nous! +33 (0)2 31 45 28 21
lcs@ensicaen.fr
  • Français
Laboratoire Catalyse et SpectrochimieLaboratoire Catalyse et SpectrochimieLaboratoire Catalyse et SpectrochimieLaboratoire Catalyse et Spectrochimie
  • Who are we?
  • Research at LCS
    • Publications
    • EDRF Projects
    • ANR projects
    • Research at LCS
      • Spectrocat group
      • Zeolithes group
    • News
    • Lab activities and organization
    • Education
    • The doctoral and postdocs blog
    • History
  • Technical platforms
    • Catalytic Tests & Chemisorption Platform
    • VISIO platform
    • Solid State NMR platform
      (NMR center of Caen-Normandy)
    • Synthesis & Characterization Platform
  • Industrial partnership
  • Contact us!
    • Work at the lab
    • Contact us!
    • Laboratory staffs
    • LCSValoris serving companies
Next Previous

Zeolite Nanoparticles Inhibit Aβ-Fibrinogen Interaction and Formation of Consequent Abnormal Structural Clot – ACS Applied Materials & Interfaces (ACS Publications)

25 October 2016

title-2

Source : Zeolite Nanoparticles Inhibit Aβ-Fibrinogen Interaction and Formation of Consequent Abnormal Structural Clot – ACS Applied Materials & Interfaces (ACS Publications)

by

Hossein Derakhshankhah, Mohammad Javad Hajipour, Ebrahim Barzegari, Alireza Lotfabadi, Maryam Ferdousi, Ali Akbar Saboury, Eng-Poh Ng, Mohammad Raoufi, Hussein Awala, Svetlana Mintova, Rassoul Dinarvand, and Morteza Mahmoudi
ACS Appl. Mater. Interfaces, Just Accepted Manuscript
DOI: 10.1021/acsami.6b10941
EMT-type zeolite nanoparticles (EMT NPs) with diameter smaller than 12 nm and uniform pore size of 7.3 Å have shown high selective affinity toward plasma protein (fibrinogen). Besides, the EMT NPs have demonstrated no adverse effect on blood coagulation hemostasis. Therefore, it was envisioned that the EMT NPs could inhibit possible β-Amyloid (Aβ)-fibrinogen interactions that result in the formation of structurally abnormal clots, which are resistant to lysis, in cerebral vessels of patients with Alzheimer disease (AD). To evaluate this hypothesis, the clot formation and degradation of Aβ-fibrinogen in the presence and absence of the EMT zeolite NPs were assessed. The results clearly showed that the delay in clot dissolution was significantly reduced in the presence of zeolite NPs. By formation of protein corona, the EMT NPs showed a negligible reduction in their inhibitory strength. Docking of small molecules (Aβ-fibrinogen) introduced novel potential inhibitory candidate. The zeolite NPs showed similar inhibitory effects on binding of fibrinogen to both Aβ (25-35) and/or Aβ (1-42). This indicates that the inhibitory strength of these NPs is independent on Aβ sequence and it is suggested that the zeolite NPs adsorb fibrinogen and specifically obstruct their Aβ binding sites. Therefore, the zeolite NPs can be the safe and effective inhibitors in preventing Aβ-fibrinogen interaction and consequent cognitive damage.

Copyright 2021 - Laboratoire Catalyse & Spectrochimie - Directeur de publication : Guillaume CLET | Creative Commons 4.0 International
  • Français
Laboratoire Catalyse et Spectrochimie
Login

Lost your password?

Reset Password

Log in